SPECTROSCOPIC EVALUATION OF THE METHANOLIC EXTRACT OF AZADIRACHTA INDICA ON THE DISSOLUTION OF METFORMIN

Abstract

Background: -Herbal remedies continue to play a significant role in the healthcare of a huge
portion of the developing world's population, particularly those living in rural regions. This is
because such communities are frequently underserved in terms of Western-style healthcare,
resulting in a larger reliance on traditional medicine for disease management, which is both
more accessible and more culturally acceptable. A drug interaction is said to occur when the
effect of one drug is changed by the presence of another substance, which may be a drug,
herbal medicine, food, drink, or an environmental chemical agent.
Aim: The study is aimed at determining the effect of Azadirachta indica on the metformin
dissolution profile.
Methods: Five samples were taken at regular intervals during the dissolving process from a
potassium dihydrogen orthophosphate medium that had been pH-adjusted to 6.8 using 0.1M
NaOH. The process of dissolution was used to replicate the pH of the gastrointestinal system
both with and without the herbal medication.
Results: The results showed that when metformin was added to the dissolving medium alone

as opposed to when it was combined with Azadirachta indica, a larger percentage of the
medicine was released.
Conclusion: As a result of the study's finding Azadirachta indica increases the percentage
release of metformin tablets. co-administration of Azadirachta indica with metformin should
be avoided. The dissolution profile of metformin was enhanced in the presence of azadirachta
indica. This may result in therapeutic failure.