STABILITY AND DISSOLUTION PROFILE OF TABLETS OF DICLOFENAC  SODIUM DISPERSIONS WITH PARKIA BIGLOBOSA-DERIVED POLYMERS

Authors

*Dagogot C.N., 2Bako W., 3Musa H., 3 Idris A.Y., Veritas University, Bwari Abuja.

Parkia biglobosa, Mucilage, Solid dispersion, Kneading, Direct compression

Background: Solid dispersion techniques is a method of enhancing dissolution of poorly

water-soluble drug. The kneading method is a simple cost-effective way of preparing solid

dispersions. Formulating tablet of solid disperse drug is a means enhancing patient access and

acceptability of the product; using natural polymeric material like Parkia biglobosa derived

polymer can lead to a cost effective and biocompatible product.

Aim: This work aims to present solid dispersion of diclofenac sodium with Parkia biglobosa

derived polymeric material prepared by kneading technique as tablet and evaluate the stability

and tableting properties of the formed tablets.

Method: A direct compressible tablet was formulated using Avicel 101 as a direct

compressible excipient. The tablets were evaluated for their tableting properties and dissolution

testing in Simulated Gastric Fluid (SGF) and Simulated Intestinal Fluid (SIF). The impact of

high temperature and long-time storage for six months on the stability of the formulation was

also evaluated.

Results: The tablets formulated were found to be of excellent tableting properties, agreeing

with official specifications. Tablets of the Modified Parkia biglobosa Mucilage (MPBM)

showed a 12% drug release in the SGF sustained for about one hour. This is a 2-fold

improvement in release profile compare to the diclofenac tablet formulated. The tablets

formulated with PBM, MPBM and Polyvinylpyrrolidone (PVP) polymers release more than

45% of diclofenac sodium within 15 mins in the SIF.

Conclusion: Formulated Tablets showed excellent tableting properties with MPBM-K tablet

showing a two-fold enhancement of the dissolution rate. The formulated tablets were stable at

45 0 C for 24 h and over a period of 6 months storage with no significant change in drug content

under these conditions with p-values of 0.201, 0.706, 0.611, 0.322 and 0.142, 0.787, 0.475 and

1.00 respectively which are greater than 0.05.

Dagogot C.N., 2Bako W., 3Musa H., 3 Idris A.Y.,

Department of Pharmaceutics and Pharmaceutical Technology, Veritas University, Bwari

Abuja.

Department of Pharmaceutics and Industrial Pharmacy, Afebabalola University Ado Ekiti

Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University Zaria

*Corresponding author: charlesdagogot@gmail.com, dagogotc@veritas.edu.ng

Tel: +234-(0)-8069807111