EVALUATION OF THE EFFECT OF VARIOUS SUPER DISINTEGRANTS ON THE DRUG RELEASE PROFILE OF OMEPRAZOLECORETABLETS

Abstract

Background: Super disintegrants play a crucial role in enhancing tablet disintegration and,
consequently, drug release. Omeprazole, a proton pump inhibitor used in treating gastroesophageal
reflux disease (GERD), will benefit from rapid disintegration and dissolution to ensure prompt
therapeutic action.
Aim: The study investigated the influence of three distinct super disintegrants—croscarmellose
sodium, sodium starch glycolate, and crospovidone—on the physical and functional properties of
omeprazole core tablets.
Methods: Tablets were formulated with varying concentrations of each super disintegrant, and the
effects on disintegration time, dissolution rate, and mechanical strength were evaluated. Results:
Each super disintegrant imparted unique characteristics to the tablets: croscarmellose sodium
facilitated faster disintegration due to its high swelling capacity, while sodium starch glycolate
provided moderated disintegration with enhanced stability. Crospovidone, known for its capillary
activity, demonstrated rapid water uptake, resulting in faster disintegration but lower mechanical
strength. Among the three, crospovidone sodium achieved the most efficient balance of
disintegration and mechanical integrity, making it favourable for rapid drug release without
compromising tablet durability.
Conclusion: These findings emphasize the importance of selecting an optimal super disintegrant
to tailor drug release profiles in omeprazole formulations, potentially improving therapeutic
efficacy and patient compliance.