AMELIORATIVE EFFECT OF ETHANOLIC EXTRACT OF BAUHINIA MONANDRA ON HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS OF PLASMODIUM BERGHEI INFECTED MICE

Abstract

Introduction: The progression of malaria is characterized by anemia and elevated serum levels

of liver enzymes.

Aim: The purpose of the study was to assess the impacts of the ethanol-based extract of B.

monandra on the hematological and biochemical parameters of Plasmodium berghei

infected mice.

Methods: A total of 25 mice were injected intraperitoneally with P. berghei (resistant ANKA

clones), while an additional 5 mice remained uninfected to act as the normal control and were

designated as group 6. The negative control (group 5) received distilled water only. The

positive control group (group 4) was treated with ACT and served as the positive control.

Meanwhile, groups 1, 2, and 3 were orally given B. monandra extract at doses of 50, 100, and

150 mg/kg body weight, respectively, for a duration of three days. The effects of the leaf extract

of B. monandra on liver enzymes (alanine aminotransferase and aspartate aminotransferase)

and hematological parameters of P. berghei-infected mice were studied using standard

methods.

Results: The parasitized control mice showed significantly elevated serum ALT and AST

activities compared to all other groups. However, parasitized mice administered the extract and

those treated with ACT exhibited similar (p > 0.05) serum ALT and AST activities.

Furthermore, each of the extract doses utilized demonstrated a stimulating effect on red blood

cell production after the treatment was administered.

Conclusion: This plant holds great promise for the amelioration of liver damage and the

formation of blood cells.